JOURNAVX Dosing Instructions

Your pain management provider at Coastal Health has prescribed you JOURNAVX™, a new medication indicated for moderate to acute pain. To get the most out of this therapy, it is important to take it according to the following dosing instructions.

How do I take JOURNAVX?

First Dose

Take Two 50mg JOURNAVX tablets by mouth on an empty stomach.

From Second Dose On

Take One 50mg JOURNAVX tablet 12 hours after the first dose, then every 12 hours.

Swallow tablets whole. Do not chew or crush the tablets.

Important: Tell your doctor about all the medicines you take, especially if you take hormonal birth control, medicines that are substrates of an enzyme called CYP3A, or if you have liver problems, as dosing instructions may vary.

Take JOURNAVX exactly as your doctor tells you to, and for as long as your doctor recommends.
Journavx Dosing
Patient taking medication

What should I know about taking JOURNAVX?

  • For the First Dose: Take it at least 1 hour before or 2 hours after food. During this time, clear liquids may be consumed (such as water, apple juice, vegetable broth, tea, or black coffee).

  • From the Second Dose on: JOURNAVX can be taken with or without food.
Avoid food or drink containing grapefruit while you are taking JOURNAVX.

What if I miss a dose of JOURNAVX?

If you miss one dose:

Take the missed dose as soon as you can. Then take your next scheduled dose.

If you miss two doses:

Take two Journavx tablets. Then take your scheduled dose.

Dosing Card

Important Safety Information

Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.

Before taking JOURNAVX, tell your Coastal Health provider about all of your medical conditions, including if you:

  • Have liver problems. People with liver problems may have an increased risk of getting side effects from taking JOURNAVX.
  • Are pregnant or plan to become pregnant. It is not known if JOURNAVX will harm your unborn baby. You and your healthcare provider should decide if you will take JOURNAVX while you are pregnant.
  • Are breastfeeding or planning to breastfeed. It is not known if JOURNAVX passes into your breast milk.

Drug Interactions

Tell your healthcare provider about all the medicines you take. Especially tell your healthcare provider if you take:

  • Hormonal birth control medicine containing progestins other than levonorgestrel or norethindrone. They may not work as well during treatment with JOURNAVX. Use nonhormonal contraceptives during treatment and for 28 days after.
  • Medicines that are substrates of the CYP3A enzyme as they may become less effective.

Possible Side Effects

The most common side effects included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash. JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.